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Glen, who is 45 years old, begins to notice that his hands shake (tremors) when he is performing everyday tasks such as signing his signature. His family members have noticed that he also has muffled speech and tends to shuffle when he walks. He is diagnosed with Early Onset Parkinson’s disease.
-What is Early Onset Parkinson’s disease?
-What specific cell type is affected in Parkinson’s disease?
-What is dopamine? What effects does dopamine have on the body?
-Explain the structure of a synapse and why Glen’s neurologist would prescribe him a dopamine agonist?
-Glen has genetic testing performed and it is determined that he does carry an autosomal dominant mutation in the SNCA gene associated with Early Onset Parkinson’s disease. Glen has three children. Would you advise his children to have genetic testing performed to determine if they also carry the disease mutation? Why or why not?
Sample Solution
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