Drug Design And Chemotherapy 2020
To include in your report:
- Background:
Include a brief background paragraph outlining the experiment(s) and the links between telomerase, aminoanthraquinones and cancer chemotherapy (supported by suitable references). [Maximum word count: 400].
- List all supporting references cited in the background and R&D text, typically 6-10, in full, and in Harvard Style [Note that the 3 references required in answer to Q4 (below) are in addition to these and are not for inclusionin the main reference list].
- Experimental: Outline the experimental procedure you carried out for t.l.c. of MSc-A, MSc-B, & MSc-C and the chlorinated anthraquinone starting materials, in sufficient detail for someone to follow and repeat what you did.
- Results and discussion:
(i) T.l.c.:
Include the Rf values of the starting anthraquinone, the final product for all three reactions (MSc-A, MSc-B and MSc-C) and any other impurities (if present, comment on what these are likely to be) in both solvent systems. Also, comment on and explain how the t.l.c. values are affected by the different polarity of solvent systems 1 and 2.Drug Design And Chemotherapy 2020
NOTE: T.l.c. plates must be either scanned in to your report (preferred) or you can attach the actual t.l.c.s to the paper copy of your submitted report (later).
Column chromatography
(ii) Percentage Yield Calculation: In reaction A, 0.25g of 1-chloroanthraquinone was reacted with the amine, 2-(2-aminoethoxy)ethanol. After purification by solvent extraction and column chromatography, 0.0406g of a red solid of pure MSc-A was obtained. Calculate the maximum theoretical % yield of product MSc-A, based on 0.25g of 1-chloroanthraquinone starting material and the percentage yield of pure MSc-A. Show all calculations in full.
(iii) Comment on the purity and % yield: Following consideration of experimental procedures, include statements on the observed purity of product MSc-A and account for variability in the amounts of isolated product (and losses) and how these could be improved.
Drug Design And Chemotherapy 2020
