Framing the Research Question: PICO (T)
Evidence-based models use a process for framing a question, locating, assessing, evaluating, and
repeating as needed. PICO (T) elements include:
Problem/Patient/Population, Intervention/Indicator, Comparison, Outcome,
and (optional) Time element or Type of Study.

  1. Frame the question: write out your information need in the form of a question, for example:
    Does hand washing among healthcare workers reduce hospital acquired infections?
    The question above includes the PICO elements:
    Example:
    P (Problem or Patient or
    Population) hospital acquired infection
    I (intervention/indicator) hand washing
    C (comparison) no hand washing; other solution; masks
    O (outcome of interest) reduced infection
  2. Plan a search strategy by identifying the major elements of your question, and translate
    natural language terms to subject descriptors, MeSH terms, or descriptors.
    TIP: start with the P and the I only to begin your search and keep initial search results broad:
    natural language term mapped to database vocabulary
    P (Problem/Patient/Population)
    = hospital acquired infection
    cross infection
    I (intervention/indicator) = hand washing
    hand disinfection
    handwashing
    A simple database search strategy should begin with the P AND I:
    cross infection AND (Handwashing OR Hand disinfection)
    Start with both CINAHL and Medline/PubMed as initial article databases for a scoping
    search for most health sciences questions.
  3. After viewing the initial search results you may decide to narrow your search with terms for
    the Comparison, Outcome, Time factors or Type of study. Or you may view results, abstracts,
    and full text of articles to view the comparison and outcome elements. Use database filters to
    narrow your search.
    *Heneghan, C., & Badenoch, D. (2002). Evidence-based medicine toolkit. London: BMJ Books
    NYU Libraries (2017). Health (Nursing, Medicine, Allied Health): Search Strategies: Framing
    the question (PICO). Retrieved from
    http://libraryguides.mdc.edu/ld.php?content_id=9456107