The Thyroid Gland Assignment Discussion
Responses to classmates must consist of at least 350 words (not including the greeting and the references), do NOT repeat the same thing your classmate is saying, try to add something of value like a resource, educational information to give to patients, possible bad outcomes associated with the medicines discussed in the case, try to include a sample case you’ve seen at work and discuss how you feel about how that case was handled. Try to use supportive information such as current Tx guidelines, current research related to the treatment, anything that will enhance learning in the online classroom. Feedback loop for the thyroid gland. Discussion post by Chad Spencer, Pictures and questions by Jessica Applet. Within the human body the thyroid hormones are regulated by a negative feedback loop. This feedback loop is responsible for maintaining tight control over the thyroid hormones and their narrow range of serum concentrations (Ortiga-Carvalho, Sidhaye, & Wondisford, 2014). This negative feedback loop involves the thyroid gland, hypothalamus, and the anterior pituitary gland (McCance, Huether, Brashers, & Rote, 2019). When the body senses low levels of triiodothyronine (T3) and tetraiodothyronine (T4) the feedback loop gets initiated. The first step in this loop is the release of thyrotropin-releasing hormone (TRH) (McCance et al., 2019). The Thyroid Gland Assignment Discussion
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TRH is stored and synthesized within the hypothalamus (McCance et al., 2019). The TRH levels within the body are increased by things such as stress, exposure to the cold, and decreased levels of T4 (McCance et al., 2019). TRH gets released into the hypothalamic-pituitary portal system, where it circulates and reaches the anterior pituitary gland (McCance et al., 2019). The anterior pituitary gland gets stimulated and causes the release of thyroid stimulating hormone (TSH) (McCance et al., 2019). TSH then stimulates the thyroid gland to produce thyroid hormone (TH) (McCance et al., 2019). As the TH levels rise it creates a negative feedback that stops the release of TRH and TSH which then results in decreased TH production and secretion (McCance et al., 2019). Questions A decrease in what leads to the initiation of the feedback loop for the thyroid gland? Where is thyrotropin-releasing hormone synthesized and release from? References McCance, K.L., Huether, S.E., Brashers, V.L., & Rote, N.S. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis: Mosby Elsevier. Ortiga-Carvalho, T. M., Sidhaye, A. R., & Wondisford, F. E. (2014). Thyroid hormone receptors and resistance to thyroid hormone disorders. Nature Reviews Endocrinology, 10(10), 582–591. https://doi.org/10.1038/nrendo.2014.143 What You Should Know About the Thyroid Feedback Loop. (2017). Picture retrieved from https://thyroidadvisor.com/know-thyroid-feedback-loop/
The Thyroid Gland Assignment Discussion
